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Bear in mind 

what can we do to optimize the surgical procedure with 3D printing technique?

what can we do to understand the tumor biology better?




</div></div></div><div class="recent-post-item"><div class="recent-post-info no-cover"><a class="article-title" href="/drduxinhui/2023/10/09/%E6%96%87%E7%8C%AE%E8%A7%A3%E8%AF%BB-RSL1D1-and-colorectal-cancer/" title="文献解读-RSL1D1 and colorectal cancer">文献解读-RSL1D1 and colorectal cancer</a><div class="article-meta-wrap"><span class="post-meta-date"><i class="far fa-calendar-alt"></i><span class="article-meta-label">Created</span><time datetime="2023-10-09T07:13:56.000Z" title="Created 2023-10-09 15:13:56">2023-10-09</time></span></div><div class="content">文献解读 RSL1D1 promotes the progression of colorectal cancer through RAN-mediated autophagy suppressionTake home message
Functional validation studies (3 main figures)

Clinical significance study related figures (Fig 1)

In vitro and in vivo cancer study designs (kd and o&#x2F;e for Fig 2 and 3, respectively)



Mechanism studies (4 main figures)

Biologicial process involvement of the model (Fig 4)

Autophage, Ferroptosis …


Interacting protein detection and validation (molecular and functional) ...</div></div></div><div class="recent-post-item"><div class="recent-post-info no-cover"><a class="article-title" href="/drduxinhui/2023/10/09/%E6%8A%80%E6%9C%AF%E7%A0%94%E7%A9%B6%E8%83%8C%E6%99%AF-3D%E6%89%93%E5%8D%B0%E6%8A%80%E6%9C%AF%E5%9C%A8%E9%AA%A8%E7%A7%91%E7%9A%84%E5%BA%94%E7%94%A8/" title="技术研究背景--3D打印技术在骨科的应用">技术研究背景--3D打印技术在骨科的应用</a><div class="article-meta-wrap"><span class="post-meta-date"><i class="far fa-calendar-alt"></i><span class="article-meta-label">Created</span><time datetime="2023-10-09T02:04:44.000Z" title="Created 2023-10-09 10:04:44">2023-10-09</time></span></div><div class="content">3D打印技术在骨科的应用随着数字化技术与骨科学的联系日益紧密，传统骨科学诊疗行为模式发生了深刻变革，逐步从经验化、大体化、轮廓化向标准化、精准化、个性化及数字化的方向发展。3D打印技术作为数字化技术的集中体现，是实现各种骨科手术个体化、精准化的有效手段。数字化设计的手术方案可以通过3D打印手术导板将手术的规划集中到导板上，使用时只需将导板接触于术前规划的部位即可引导术者按照术前规划顺利进行术中定位、定点、线、面及其方向和深度，从而精确引导钉道方向和深度,确定截面、距离和相互成角关系等，使手术操作的精准性和安全性大大提高、手术时间缩短、术中出血和副损伤减少；使一些传统手术比较复杂、困难的术中操作变得容易和轻松；减少了术中C型臂X线机的依赖和手术室射线沾染，减少了手术相关并发症；其技术的普及应用极大改善和提高了骨科的救治水平，有效提高了骨科手术质量。
应用类型3D打印技术在临床使用有一定的学习曲线，根据使用的方法可以大概分为4个层级。
第一个层级是指3D打印组织模型的使用，是应用最早、最多且最简单的使用方式。可用于疾病解剖结构展示、手术方案制定、医疗教学等领域。
第二个层级是打印导板的应用 ...</div></div></div><div class="recent-post-item"><div class="recent-post-info no-cover"><a class="article-title" href="/drduxinhui/2023/10/09/%E5%A4%96%E7%A7%91%E6%96%B0%E6%8A%80%E6%9C%AF-3D%E6%89%93%E5%8D%B0%E6%8A%80%E6%9C%AF%E8%BE%85%E5%8A%A9%E4%B8%8B%E7%BA%BF%E9%94%AF%E7%B2%BE%E5%87%86%E6%88%AA%E9%AA%A8%E6%8A%80%E6%9C%AF/" title="外科新技术--3D打印装置辅助下线锯精准截骨技术">外科新技术--3D打印装置辅助下线锯精准截骨技术</a><div class="article-meta-wrap"><span class="post-meta-date"><i class="far fa-calendar-alt"></i><span class="article-meta-label">Created</span><time datetime="2023-10-08T23:45:20.000Z" title="Created 2023-10-09 07:45:20">2023-10-09</time></span></div><div class="content">外科新技术–3D打印装置辅助下线锯精准截骨技术技术适应证骨盆、骶骨等不规则骨的切除手术。
本技术所需特殊设备软件设备3D slicer， 3D Builder （均为开源软件）
硬件设备3D 打印机， PLA材料
手术设备创伤骨科使用电钻，软钻头和导向器
技术实施过程
数字化建模，设计切除方案

导板设计与打印

匹配依赖截骨区域的骨性结构

在预截骨平面预留两个孔方便术中操作



手术操作 (重点切除范围为骨骼及附着的韧带)

骨膜下剥离截骨平面骨质，导板术中匹配

钻孔，取下导板，孔内导入线锯截骨

剩余区域骨刀截骨




技术创新点
新的3D打印导板设计模式

以往的导板多需要两个模块，而本设计将两个模块融合为一个模块，也即在定位模块上预留孔作为截骨的导向通道，两个孔就可确定截骨线和平面。该设计大大减少了设计及打印成本，操作更加简单。

可控的精准截骨方法

以往的截骨导板的使用包括导板与术区的匹配，导板的固定以及摆锯或者骨刀截骨等过程，操作复杂。轻微的导板形变或者导板固定不牢靠均可导致位置变动影响截骨准确性。另外导板能确定一条线而非一个平面，术中切除过程中往往存在截面角度的 ...</div></div></div><div class="recent-post-item"><div class="recent-post-info no-cover"><a class="article-title" href="/drduxinhui/2023/10/08/%E6%8A%80%E6%9C%AF%E7%A0%94%E7%A9%B6%E8%83%8C%E6%99%AF-%E5%85%A8%E8%84%8A%E6%A4%8E%E5%88%87%E9%99%A4%E6%9C%AF/" title="技术研究背景--全脊椎切除技术">技术研究背景--全脊椎切除技术</a><div class="article-meta-wrap"><span class="post-meta-date"><i class="far fa-calendar-alt"></i><span class="article-meta-label">Created</span><time datetime="2023-10-08T12:31:51.000Z" title="Created 2023-10-08 20:31:51">2023-10-08</time></span></div><div class="content">全脊椎切除术研究背景适应症全脊椎切除术适用于脊柱肿瘤的外科切除，以局部根治为目的，多用于侵袭性或局限性恶性原发骨肿瘤，部分也有报道进行脊柱寡转移灶的切除。
手术特点全脊椎切除手术难度大，风险高。复旦大学附属中山医院董健主任汇报了一组进行全脊椎切除的患者，其中包含5例原发骨肿瘤及4例转移瘤。该组患者进行了一期后路手术，其中6例患者进行2个椎节切除，2例患者切除了3个椎节而剩余的1例进行了4椎节肿瘤切除。该组患者手术时间平均8.9小时（7-16小时），术中出血量平均3422ml（1700-6000ml），住院时间平均为31天（14-73天）。其中3例患者术中出现硬膜撕裂，1例患者出现胸膜破裂，3例患者术后出现胸腔积液，1例术后出现胸腔感染。术后8个月、18个月及28个月各有一例患者出现局部复发。随访中有4例患者死亡，其中3例患者死于多发转移，1例患者死于肿瘤复方引起恶并发症，中位生存时间为34.75个月。

 [1]梁运,刘鹏,周晓岗,李熙雷,林红,董健.一期后路全脊椎切除术治疗多椎节脊柱肿瘤[J].中国脊柱脊髓杂志,2017,27(9):781-786.DOI:10.3969&#x2F; ...</div></div></div><div class="recent-post-item"><div class="recent-post-info no-cover"><a class="article-title" href="/drduxinhui/2023/10/08/%E5%A4%96%E7%A7%91%E6%96%B0%E6%8A%80%E6%9C%AF-%E5%81%8F%E5%BF%83%E6%88%AA%E9%AA%A8%E5%85%A8%E8%84%8A%E6%A4%8E%E5%88%87%E9%99%A4%E6%8A%80%E6%9C%AF/" title="外科新技术--单后路偏心截骨胸腰椎全脊椎切除技术">外科新技术--单后路偏心截骨胸腰椎全脊椎切除技术</a><div class="article-meta-wrap"><span class="post-meta-date"><i class="far fa-calendar-alt"></i><span class="article-meta-label">Created</span><time datetime="2023-10-08T11:05:08.000Z" title="Created 2023-10-08 19:05:08">2023-10-08</time></span></div><div class="content">技术名称：单后路偏心截骨胸腰椎全脊椎切除技术技术适应症
原发侵袭性或恶性骨肿瘤

孤立转移性骨肿瘤


特殊设备创伤骨科用钻头，导向器及电钻
技术实施过程
俯卧位后正中切口，常规显露置钉，切除椎板及椎弓根（用超声骨刀切除），处理双侧神经根（结扎或保护）

充分游离椎体侧方及前方结构（前方会师并填塞纱垫），健侧上棒并撑开

偏心截骨技术：

以钻头在患侧硬膜旁导向器辅助下经椎体或椎间盘向健侧侧前方建立通道，导入线距截骨（前纵韧带及大部分椎体）

在健侧导入线锯，以卵圆钳将线锯压低，水平截骨（后纵韧带及剩余的小部分椎体）



另一个截骨平面重复进行偏心截骨，将肿瘤向患侧旋转，整块切除肿瘤组织。


技术创新点
建立线锯的骨性通道，将前后纵韧带均包含在线锯截骨范围内，轻松进行前后纵韧带及椎体的截骨。

骨性结构及韧带的锐性精准切除，可显著减少取出肿瘤时对肿块的推挤，降低术中肿瘤破溃的风险。

偏心通道设计，方便线锯安放，显著减少操作时间。

偏心通道设计，减少了对硬膜的推挤，安全性大大提高。


技术优势全脊椎横断面截骨通过两步实现，在不显著特殊手术器械及手术成本的前提下通过改进截骨技术提 ...</div></div></div><div class="recent-post-item"><div class="recent-post-info no-cover"><a class="article-title" href="/drduxinhui/2023/10/07/%E5%B8%B8%E7%94%A8%E7%BD%91%E7%AB%99%E5%AF%BC%E8%88%AA/" title="常用网站导航">常用网站导航</a><div class="article-meta-wrap"><span class="post-meta-date"><i class="far fa-calendar-alt"></i><span class="article-meta-label">Created</span><time datetime="2023-10-07T12:49:10.000Z" title="Created 2023-10-07 20:49:10">2023-10-07</time></span></div><div class="content">常用网站导航1. 个人信息郑大邮箱
Ongoing list
个人简历 | 个人照片 
课题信息
临床大体照片展示临床大体照片
技术展示R codes
1 腰3转移瘤
2 腓骨近端骨肿瘤
工作资料备份论文备案文件2024
投稿通用信息科研团队邮箱  |
常用网站链接关注的期刊信息 | NCCN指南2023
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</div></div></div><div class="recent-post-item"><div class="recent-post-info no-cover"><a class="article-title" href="/drduxinhui/2023/10/07/RPs-and-cancer-reveiw/" title="RPs and cancer reveiw">RPs and cancer reveiw</a><div class="article-meta-wrap"><span class="post-meta-date"><i class="far fa-calendar-alt"></i><span class="article-meta-label">Created</span><time datetime="2023-10-07T05:05:15.000Z" title="Created 2023-10-07 13:05:15">2023-10-07</time></span></div><div class="content">Ribosome proteins and cancer: biological roles and its molecular regulation1. Ribosome proteins: compositions and their conventional roles2. Deregulation of ribosome proteins and its biological roles in cancer- Tumor promoting roles- Tumor inhibiting roles- Drug resistance3. Clinial significance of ribosome protein deregulation in cancer therapy- Preclinical studies- Ongoing clinical trials- Future study directions4. Conlusion remarks</div></div></div><div class="recent-post-item"><div class="recent-post-info no-cover"><a class="article-title" href="/drduxinhui/2023/10/05/%E8%9B%8B%E7%99%BD%E7%BB%84%E5%AD%A6%E6%8A%80%E6%9C%AF%EF%BC%88%E4%BA%8C%EF%BC%89/" title="蛋白组学技术（二）">蛋白组学技术（二）</a><div class="article-meta-wrap"><span class="post-meta-date"><i class="far fa-calendar-alt"></i><span class="article-meta-label">Created</span><time datetime="2023-10-05T03:25:23.000Z" title="Created 2023-10-05 11:25:23">2023-10-05</time></span></div><div class="content">蛋白组学实验技术（二）1.什么是PRM？
答：
PRM（Parallel Reaction Monitoring，平行反应监测）是一种基于高分辨、高精度质谱的靶向定量技术，能够对目标蛋白质&#x2F;肽段（以及含有修饰的肽段）进行选择性检测，从而实现对目标蛋白质&#x2F;肽段的相对&#x2F;绝对定量。
2.PRM绝对定量和相对定量有什么区别？
答：
蛋白PRM验证可以选择通用的内标肽进行，也可以用合成的目标蛋白的内标肽进行，都可以准确的反映蛋白的含量。其中相对定量用的是通用的内标肽，而绝对定量用的则是合成目标蛋白的内标肽段，每个需要进行验证的蛋白都需要一条特定的内标肽段来对蛋白进行绝对定量。
3.PRM筛选目标肽段，需要用同位素标记吗？
答：
筛选目标肽段的时候不需要同位素标记。同位素标记的内参是为了定量更准确，如果是相对定量，所有肽段用一条同位素标记内参做校正即可，如果是绝对定量，就需要合成与检测肽段序列一致的同位素肽段。
4.PRM实验时，一般要求提出来的峰丰度达到多少才能做到定量准确呢？
答：
PRM检测对于峰的丰度来说，没有绝对的标准。在挑选定量肽段时，一般都是尽可能挑丰度 ...</div></div></div><div class="recent-post-item"><div class="recent-post-info no-cover"><a class="article-title" href="/drduxinhui/2023/10/05/%E8%9B%8B%E7%99%BD%E7%BB%84%E5%AD%A6%E6%8A%80%E6%9C%AF%EF%BC%88%E4%B8%80%EF%BC%89/" title="蛋白组学技术（一）">蛋白组学技术（一）</a><div class="article-meta-wrap"><span class="post-meta-date"><i class="far fa-calendar-alt"></i><span class="article-meta-label">Created</span><time datetime="2023-10-05T03:25:04.000Z" title="Created 2023-10-05 11:25:04">2023-10-05</time></span></div><div class="content">蛋白组学实验技术（一）1. 蛋白质组（Proteome）的概念
蛋白质组（Proteome）的概念最先由Marc Wilkins提出，指由一个基因组（Genome），或一个细胞、组织表达的所有蛋白质（Protein）。蛋白质组的概念结合了基因组的概念，同时引入了蛋白质的概念，意指“一种基因组所表达的全套蛋白质”，即包括一种细胞乃至一种生物所表达的全部蛋白质。
蛋白质组学本质上指的是在大规模水平上研究蛋白质的特征，包括蛋白质的表达水平，翻译后的修饰，蛋白与蛋白相互作用等，由此获得蛋白质水平上的关于疾病发生，细胞代谢等过程的整体而全面的认识。
2. 蛋白组学相关实验技术包含哪些呢？
答：
a) 定性蛋白质组：鸟枪法（Shotgun）（常见胶条鉴定，或只有一个样本的情况）；
b) 定量蛋白质组：Label-free、DIA、iTRAQ&#x2F;TMT、PRM；
c) 修饰蛋白质组：磷酸化修饰蛋白质组学、乙酰化修饰蛋白质组学、泛素化修饰蛋白质组学、糖基化修饰蛋白质组学、甲基化修饰蛋白质组学、乳酸化修饰蛋白质组学、巴豆酰化修饰蛋白质组学、二羟基异丁酰化修饰蛋白质组学、琥珀酰化修饰蛋白质组学；
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